Cytotoxic Chalcones fromDesmodium oxyphyllum
نویسندگان
چکیده
منابع مشابه
Synthesis and cytotoxic evaluation of alkoxylated chalcones.
A series of chalcones a1-20 bearing a 4-OMe groups on the A-ring were initially synthesized and their anticancer activities towards HepG2 cells evaluated. Subsequently, a series of chalcones b1-42 bearing methoxy groups at the 2' and 6'-positions of the B-ring were synthesized and their anticancer activities towards five human cancer cell lines (HepG2, HeLa, MCF-7, A549 and SW1990) and two non-...
متن کاملCytotoxic activity evaluation and QSAR study of chromene-based chalcones.
Chalcone and chromene motifs are synthetic or naturally occurring scaffolds with significant cytotoxic profile. Two types of novel regioisomeric chromene-chalcone hybrids, namely 1-(6-chloro or 6-methoxy-2H-chromen-3-yl)-3-phenylprop-2-en-1-one (Type A) and 3-(6-chloro or 6-methoxy-2H-chromen-3-yl)-1-phenylprop-2-en-1-one (Type B), both with different substituents on the phenyl ring attached to...
متن کاملCytotoxic chalcones and flavonoids from the leaves of Muntingia calabura.
Two new dihydrochalcones, 2',4'-dihydroxy-3'-methoxydihydrochalcone, (-)-3'-methoxy-2',4',beta-trihydroxydihydrochalcone, a new flavanone, (2 S)-(-)-5'-hydroxy-7,3',4'-trimethoxyflavanone, and a new flavonol derivative, muntingone, along with sixteen known compounds, were isolated from the leaves of Muntingia calabura. The structures of these new compounds were determined using spectral analyse...
متن کاملCytotoxic activity evaluation of chalcones on human and mouse cell lines
Background The Brazilian National Cancer Institute (INCA) estimated last year almost forty thousand new cancer cases of laryngeal carcinoma, melanoma, tracheal, bronchial and lung cancer. It is known that multidrug resistance and unspecific toxicity are the major challenges for commercial anticancer drugs [1]. In this regard, natural compounds and derivatives are considered as a source of novel...
متن کاملSynthesis and Selective Cytotoxic Activities on Rhabdomyosarcoma and Noncancerous Cells of Some Heterocyclic Chalcones.
Chemically diverse heterocyclic chalcones were prepared and evaluated for cytotoxicity, aiming to push forward potency and selectivity. They were tested against rhabdomyosarcoma (RMS) and noncancerous cell line (LLC-PK1). The influence of heteroaryl patterns on rings A and B was studied. Heterocycle functionalities on both rings, such as phenothiazine, thiophene, furan and pyridine were evaluat...
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ژورنال
عنوان ژورنال: Journal of the Brazilian Chemical Society
سال: 2015
ISSN: 0103-5053
DOI: 10.5935/0103-5053.20150034